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Yes, skin brightening treatments are highly effective in addressing pigmentation issues

Reactive ROS and RNS to reduce ROS accumulation, mitochondrial damage, inflammatory response and ferroptosis, and polyphenols also regulate the Nrf2 by activating the PI3K/AKT signaling pathway

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The incidence of adverse reactions was similar in both intervention and placebo groups

Additionally, in SH-SY5Y cells, melatonin increased levels of Peptidyl-Prolyl cis-trans Isomerase NIMA-Interacting 1 (Pin1) [125], which has been shown to mitigate tau phosphorylation and aggregation [126]

Despite these advances, clinical deployment of AI models remains constrained by uneven data quality, algorithmic bias, and a paucity of large-scale external validation