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10.1073/pnas.0709259105 225 LiaoS.ChenL.SongZ.HeH

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ROS accumulation triggers OS, cellular damage, mitochondrial dysfunction, A deposition, Tau hyperphosphorylation, synaptic loss, and neuronal deathkey factors in AD progression (Aliev et al., 2004

4.6 Relationship between cholinergic system abnormalities and ferroptosis in AD 4.6.1 Relationship between abnormal acetylcholine synthesis/degradation and ferroptosis in AD Cholinergic neurons are widely distributed in the human brain and play crucial roles in neurogenesis, neuronal differentiation, and synaptic plasticity (Long and Holtzman, 2019)