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We would not expect a close match to the clinically observed percentage changes because we are comparing intracellular model changes to blood measurements

Alam M, Abbas K, Mustafa M, Usmani N, Habib S

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Nrf2 improves endothelial function by resisting oxidative stress and mitochondrial damage, thereby delaying atherosclerosis (245)

Although ADCs with higher DARs have expectedly greater in vitro potency, preclinical studies suggest that they may be subject to more rapid hepatic clearing and a less favorable safety profile, eventually lowering their therapeutic index [18]

Recently, a novel Candida species , Candida auris has been identified with significant mortality and morbidity, as well as a high degree of anti-fungal resistance 8,9