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This dimeric form of Prx2 is non-functional, but the disulfide bridge between the subunits can be broken by Trx, regenerating Prx2, and completing the catalytic cycle [73]

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Ethical considerations All animal experiments were performed in accordance with the ARRIVE guidelines, the Animal Care Guidelines of the University of Occupational and Environmental Health, Japan (UOEH.J.) and the National Institute of Advanced Industrial Science and Technology (AIST)

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