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These multiple mechanisms of action, including antioxidant, anti-inflammatory, and anti-apoptotic pathways, are integrated and visually summarized in Figure 2

In addition to functional analysis, the mitochondrial DNA copy number was measured via quantitative PCR to determine mitochondrial biogenesis

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Schaffer S, Kim HW

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Research demonstrates that local ice application produces measurable anti-inflammatory effects comparable to whole-body cryotherapy for localized injuries