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Reduces excess melanin production, making this an effective skin brightening cream kojic acid solution for dull and uneven skin

doi: 10.1097/MOL.0b013e32832d3a10

247 Excessive production of QUIN, an NMDAR agonist, stimulates the release of glutamate and inhibits reuptake, leading to neuronal excitotoxicity

Taquet M, et al

As estradiol levels are responsible for painful uterine contractions of primary dysmenorrhea, through the increase of prostaglandin F2, histamine can also be considered a contributing factor