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An estimated 70,000 people in the US were diagnosed with malignant melanoma in 2007 in which most of them were cured but even so, there is approximately the count of 1000 people that died each year from melanoma skin cancer

Human embryonic kidney cells 293 (HEK293), Madin Darby canine kidney cells (MDCK), and B 16F10 murine melanoma cells were grown in DMEM, 10% fetal bovine serum (FBS)

Oxidative stress is defined as a pathophysiological mechanism which appears at the moment of disturbance in the balance between the production of reactive oxygen species (ROS) and antioxidant defenses ( There are theories that oxidative stress mechanisms have been implicated in the pathogenesis of psychiatric disorders

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doi: 10.1016/j.cell.2010.01.022 10 BayraktarRBertilaccioMTSCalinGA

PubMed Scholar Kahr WH, Hinckley J, Li L