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In addition, xCT, the specific subunit of system x is upregulated in the vicinity of senile plaques, probably in microglia, in Thy1-APP 751 mice (TgAPP) expressing human APP bearing the Swedish (S: KM595/596NL) and London (L: V6421) mutations as well as after A injection in the hippocampus (Qin et al., 2006)

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Laugmentation relative de la masse grasse prolonge quant elle laction de certains mdicaments lipophiles, tandis que la baisse des fonctions rnale et hpatique ralentit llimination des mdicaments ainsi que, parfois, de leurs mtabolites actifs ou toxiques, favorisant leur accumulation et augmentant le risque deffets indsirables

Pinkston, and R.J

J Neural Transm 127:189203