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Mutations in the human orthologue of the mouse underwhite gene ( uw ) underlie a new form of oculocutaneous albinism, OCA4

Herein, we identify unique temporal expression patterns of Hb-a1 mRNA and Hb protein in both CD4 + and CD8 + T-lymphocytes, with the loss of Hb in T-lymphocytes exhibiting a decrease in mitochondrial metabolism, increase in proinflammatory cytokine production after 24-hour activation, and a decreased threshold for activation compared to wild-type (WT) T-lymphocytes

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