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Using bleomycin to induce lung fibrosis in a mouse model, Chen and colleagues found that Wnt7a and Wnt10b were significantly elevated over several other elevated Wnt genes in myofibroblasts [105]

however, several of the reported interactions are not a single pattern, rather they are both synergistic and antagonistic

However, with exposure to stimuli such as oxidative/xenobiotic stress, Nrf2 escapes from Keap1-mediated repression and translocates to the nucleus, where it dimerizes with small musculoaponeurotic fibrosarcoma proteins (sMaf)

March, pp

Parker W, Hornik CD, Bilbo S, et al

Another interesting model to explore with a modified reactive host environment is the depletion of microglia