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10.1186/ar2861 330 ZhangY.XiongC.KudelkoM.LiY.WangC.WongY

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GSH dysfunction not only impairs GPX4 activity but also mobilizes intracellular Fe 2 + , thereby accelerating lipid peroxidation and ferroptotic death 131,132

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Coordinated circadian patterns of these key physiological measures are crucial for meeting the increased physical demands of the active part of the day and the reduced demands of sleep