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Hydroxocobalamin is classified as Pregnancy Category C in the United States, indicating that risk to the fetus cannot be ruled out in the absence of definitive human data

The worldwide prevalence and geographic distribution of PSC are undefined, as most epidemiologic data come from Northern Europe and the upper Midwest in the United States

A similar correlation between intestinal barrier function and fecal microbial alterations has also been shown in alcohol-dependent patients (149, 164)

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