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Description

There is no clear evidence that patients with Chronic liver disease (CLD) have a greater incidence of Drug-induced liver injury (DILI)

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Interestingly, SIRT6, another sirtuin member, can deacetylate SKP2 on K73 and K77 to enhance its further phosphorylation S72 and S75 mediated by AKT and CK1, respectively, thus preventing the APC-Cdh1 E3 ubiquitin-ligase-mediated degradation 74,75

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Scortegagna, M., Kim, H., Li, J.-L., Yao, H., Brill, L

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Int J Mol Sci 22(4):1599 Gombik K, Detka J, Kukla-Bartoszek M, Maciejska A, Budziszewska B (2022) Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism

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