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In recent years, studies on SZ bodily fluids have consistently reported increased numbers of TLR4-positive monocytes and elevated TLR4 expression in the peripheral blood of schizophrenia patients (149, 153155), suggesting that TLR4 upregulation is a key factor in the immunopathological process of schizophrenia

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185,186 Furthermore, regular physical activity improves overall health and quality of life and reduces the risk of related conditions, such as diabetes, obesity, and hypertension, that are associated with more rapid progression of CKD