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Here, we examined the ability of MM-201 to protect mammalian sensory hair cells from aminoglycoside damage to further evaluate MM-201's clinical potential

Subsequent work by Pickart and Margolina identified clusters of affected genes spanning DNA repair, antioxidant defense, ubiquitinproteasome activity, anti-inflammatory signaling, and tissue remodeling [2]

Modulation of gene expression in pineal and peripheral tissues, including genes tied to circadian rhythm regulation, melatonin synthesis, stress response, and cell-cycle control