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doi: 10.1016/j.neuropharm.2010.04.005 252

Huff LM, Lee J-S, Robey RW, Fojo T

Preclinical studies indicate that simultaneous or near-simultaneous administration produces maximal synergy, with synergistic effects declining as the interval between administrations exceeds 15-30 minutes

This targeted approach is what made it such a promising candidate for an anti-obesity drug and what continues to make it a fascinating subject for metabolic research today

Much less effective against against nerve gases that have already inhibited cholinesterase and aged to a resistant form Pralidoxime may make the symptoms of myasthenia gravis worse