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doi: 10.3389/fphys.2021.754638 Received 06 August 2021 Accepted 05 October 2021 Published 05 November 2021 Volume 12 - 2021 Edited by Helene Guizouarn, Centre National de la Recherche Scientifique (CNRS), France Reviewed by John Stanley Gibson, University of Cambridge, United Kingdom

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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) provides the most accurate plasma quantification of KLOW peptide with detection limits in the low nanomolar range, allowing clearance tracking down to 510% of peak concentration