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It provides powerful anti-inflammatory modulation that complements the repair and regeneration actions of the other three peptides

One of these target genes is the myofibroblast marker -SMA (104, 105)

Following oral administration, EGCG exhibits a mean peak plasma concentration between 1.3 and 2.2 h, a half-life ranging from 1.9 to 4.6 h, and is almost completely metabolized within 24 h (198)

Piya S, PhD, Ma H, MS, Sharma P, PhD, Kojima K, MD, PhD, Ruvolo V, MS, Basyal M, BSc, Baran N, PhD, MD, Weetall M, PhD, Sheedy J, BS, MSc, Ray B, PhD, Andreeff M , MD, PhD, Borthakur G, MD

ERis widely acknowledged for its antiproliferative properties and its antagonistic impact on ER-mediated proliferation

Ferroptosis leads to macrophage polarization toward the M1 phenotype, releasing pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6, which also aggravate renal inflammation and fibrosis