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Hsieh MJ, Lee CH, Chueh HY, et al

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Dynamic contrast-enhanced magnetic resonance imaging A commonly employed imaging technique to measure subtle BBB permeability is DCE MRI, which utilizes continuous scanning prior to and after injection of an intravenously administered gadolinium-based contrast agent (GBCA) to measure the change in gadolinium concentration in the brain (Heye et al., 2014

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In contrast, the AIM-HIGH (Atherothrombosis intervention in metabolic syndrome with low HDL/high triglycerides: impact on global health outcomes) trial, which examined the incremental effect of extended-release nicotinic acid (1.5-2 g/day) on 3,414 patients who had established CVD and atherogenic dyslipidemia and were treated with simvastatin (+/- ezetimibe), provided disappointing results

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