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In that study, the authors used young adult (8-10 weeks old) male C57BL/6 mice and performed a dosage screen (from 0.1% to 0.6%) by examining the demyelination in the corpus callosum of cerebral white matter, a brain region where the extent of demyelination can be scored more easily and consistently than the previously described superior cerebellar peduncles with LFB-PAS staining (Skripuletz et al., 2011)

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57 In totality, other resident bacteria and parasite commensals can have an antagonistic or synergistic immunosuppressive effect

Researchers are responsible for ensuring compliance with all applicable local regulations governing the use of research compounds