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In contrast, when we expressed unc1 across the nervous system using the panneuronal promoter of the rab3 gene, unc1(vlt10) animals had substantially reduced polyQ aggregation in all stages (Fig 2A), with no effect on the expression of the transgene (Fig 2A)

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Additionally, glycerolipid synthesis facilitates membrane phospholipid remodeling, releasing polyunsaturated fatty acids (PUFAs) from the membrane, thereby regulating lipid peroxidation to preserve cellular integrity

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Additional support comes from case series and long-term follow-ups by prolotherapy practitioners

Increased muscle strength helps to prevent things like slips, trips, and falls that become more common with age