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Diabetes Care 30:28802885 Biesemann N, Ried JS, Ding-Pfennigdorff D et al (2018) High throughput screening of mitochondrial bioenergetics in human differentiated myotubes identifies novel enhancers of muscle performance in aged mice

Results showed that overexpressing ATF2 in 293 T cells enhanced the luciferase activity of the WT vector by 3.2-fold, whereas E3-MUT site only increased the activity by 1.1-fold (Fig

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The release of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, drive a cytokine storm, and in such cases, antioxidant therapy may alleviate oxidative stress but also fail to address the underlying cytokine storm, limiting its therapeutic efficacy [94]

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