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Percentages of sperm cells with lipid peroxidation and intracellular ROS were analyzed using a FACS-Calibur flow cytometer (Becton Dickinson, USA)

CnoX Is a Chaperedoxin: A Holdase that Protects Its Substrates from Irreversible Oxidation

125,126,127,128,129,130,131 To date, two RNAi therapeutics, ONPATTRO and GIVLAARI, have been approved for commercial application, and two siRNAs, lumasiran (ALN-GO1) and inclisiran, have been submitted for new drug application (NDA) to the FDA