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Tamura R, Tanaka T, Yamamoto Y, Akasaki Y, Sasaki H

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As an example, a woman with rheumatoid arthritis was treated with tocilizumab, a humanized monoclonal antibody of class IgG1, targeting interleukin-6 receptors, and developed painful fatty masses of her knees documented by MRI (228)

PLoS ONE 9, e85115

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The interaction between polyphenols and mitochondria can also regulate the activation of various downstream pathways in cells through ROS generated by mitochondrial oxidative stress, thereby influencing the onset and progression of neurodegenerative diseases (Fig