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Res./Rev

ACT) and by 34% in those treated with TCH ( p = 0.017) 56,57

10.1016/j.cell.2011.02.013 103

Subsequent studies evaluated the effects of chronic treatment with a phosphodiesterase 5 inhibitor (sildenafil) in rats surgically treated with portacaval shunting, finding increased IL-1 and TNF- levels in the hippocampus along with increased levels of the subunits 1 of the GABA-A receptor and GluR2 of the AMPA receptor