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Studies have found that these exhausted T cells highly express inhibitory receptors, such as PD-1, and their gene expression profiles also undergo significant changes, exhibiting a unique transcriptional signature (41, 42)

Pallard FV, Degan P, dIschia M, Kelly FJ, Zatterale A, Calzone R, Castello G, Fernandez-Delgado R, Dunster C, Lloret A, Manini P, Pisanti MA, Vuttariello E, Pagano G

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Moreover, intercellular signaling - beyond intracellular changes - has been shown to play a critical role, leading to numerous novel findings [24]

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