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Related SNPs are rs526934 and rs34324219

This mechanism is increasingly recognized as central to depression, anxiety, and cognitive decline

Box: Hydroxocobalamin dosing schedule for the management of pernicious anaemia If no neurological involvement: Loading dose: 1,000 micrograms three times per week for two weeks Maintenance dose: 1,000 micrograms every two to three months If neurological involvement: Loading dose: 1,000 micrograms every other day until no further improvement Maintenance dose: 1,000 micrograms every two months Injections are usually administered at a GP surgery, although some patients can be taught to self administer[22]

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Several large community studies indicate that, based on the measures of tHcy and MMA levels, the B12 inflection points fall between 200 and 500 pmol/L

Most side effects are mild and transient, such as temporary injection site discomfort or minor bruising that resolves within 2448 hours