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Alox12/15 Arachidonate 12/15-lipoxygenase (ALOX12/15) is a key enzyme involved in the metabolism of polyunsaturated fatty acids (PUFAs), primarily arachidonic acid, which is oxidized to produce bioactive lipids such as 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE)

Bhamidipati D, Singh Raghav KP, Morris VK, Kopetz S , Kee BK, Johnson B, Willis J, Dasari A, Morelli MP, Parseghian CM, Lee MS, Le P, YC Shen JP, Ludford K, Overman MJ

17: Elsevier

McFarland, K

The American Diabetes Association (ADA) recommends considering periodic measurement of vitamin B12 levels in patients with type 2 diabetes taking metformin, particularly those with anemia or peripheral neuropathy, though no specific monitoring interval is specified

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