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(2021) 404(Pt B):124050

Additionally, the improvements were durable, with both GAIS scores and patient-reported outcomes remaining consistent at 12 and 22 weeks, suggesting sustained regenerative benefits from the exosomes

Blinding was not performed during animal experiments and data collection, but outcome assessments (e.g., IHC scoring) were conducted by blinded investigators

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Chronic functional bowel syndrome worsens gut-brain axis dysfunction, neuroinflammation, cognitive impairment, and vulnerability to dementia

Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al