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For more on David Sinclair and the supplements he takes, including Resveratrol and NMN, see this separate post

Fat Reduction: Enhances fat metabolism, particularly visceral fat, without affecting lean mass

6-Hydroxy-dopamine induced degeneration of central monoamine neurons

They point out that particulate air pollution has been associated with cardiovascular disease but they do not appear to have considered this as a possible confounder, although evidence of increased particulate levels was reported by Middlebrook et al