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Future research should explore immune-modulatory interventions, such as leveraging the JAK/STAT pathway for neuroprotection and enhancing innate and adaptive immune clearance of toxic aggregates [176,177]

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Other residues from subunit-B helices D (residues 81 - 85) and E (residues 109 - 132) were also involved in ligand binding

Through AKT, the binding of insulin to its receptor starts a cascade of kinase activity (Ahmed et al., 2014)

Quantitative data was presented as means SEM from a minimum of three independent experiments