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Avoid repeated freeze-thaw cycles that may degrade the amino acid structure and compromise research results

Importantly, even in the absence of full caspase activation, BAX/BAK-mediated membrane permeabilization can still cause mtDNA leakage and trigger inflammatory responses [79]

Short follow-up periods hinder assessment of sustained effects (Ogunro and Ofeniforo 2024)

Inhibition of renal prostaglandin synthesis can lead to a variety of detrimental effects if kidney function is less than optimal, including fluid and electrolyte disorders, acute renal dysfunction, nephrotic syndrome, interstitial nephritis, and renal papillary necrosis

The findings aim to provide actionable insights for policymakers, clinicians, researchers and patients to advance DHT-driven, patient-centric approaches, ultimately improving patient outcomes and addressing the unmet medical needs of rare disease populations worldwide, ensuring they have equitable access to innovative treatments and improved healthcare

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