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In addition, the dual InsR/IGF-IR inhibitor linsitinib can prevent the emergence of breast cancer cells that are resistant to long-term estrogen deprivation or antiestrogen treatment and inhibit growth of established ER+ breast cancer xenografts in ovariectomized mice [107]

Secondly, a significant dose-exposure blind spot exists in interventions: the oral bioavailability of resveratrol, curcumin, etc., is less than 5%, and 60% of phase II trials did not measure blood drug concentrations

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Spermine was positively related to butyrate but negatively related to screen time and TNF-

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