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Numerous ex vivo organ culture studies and large animal models, including rats, rabbits, dogs, and pigs, have demonstrated that minimally invasive injection or percutaneous implantation of hydrogels loaded with transforming growth factor-3, anti-apoptotic miRNA, or autologous mesenchymal stem cells can maintain IVD height, restore its viscoelastic storage modulus, and delay or even partially reverse tissue degeneration (Yang S

Data availability The data that support the findings of this study are listed in the article and are available from the corresponding author upon reasonable request

10.1007/s40495-021-00276-3 176 RoltaR.SalariaD.SharmaP.SharmaB.KumarV.RathiB.et al (2021a)