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Mszros M, Phan THM, Vigh JP, Porkolb G, Kocsis A, Pli EK, et al

Exome sequencing reveals VCP mutations as a cause of familial ALS

However, it requires daily injection, is expensive, and carries a boxed warning regarding long-term use

Signals of thiomethyl metabolites were always low for blood samples collected less than 6h apart, showing that elimination of NAPQI (either after conjugation to glutathione or the antidote) is also subject to a delay in case of acute intoxication

If methylation is impaired, less homocysteine enters transsulfuration which reduces cysteine production

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