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2016 SUSTAIN-6 reported a reduction in major adverse cardiovascular events among high-risk participants, expanding research interest beyond glucose and weight

Fig.3 Folate-independent pathway

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Expired glutathione does not suddenly become harmful in most cases, but it may lose potency, meaning it may no longer provide the same level of antioxidant support

While it should be kept in mind that juvenile and adult SLE are two clinically distinct diseases 47 , in which circulating neutrophils may be likely exposed to different mediators and, eventually, function diversely, other factors might explain the differences between our results and those by Garcia-Romo and collegues 25