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The double-blind multicenter phase 3 trials STEP 1, 3, 4, 5 were conducted in adults (mean age 46.247.3 years), mostly females, with obesity or overweight with 1 weight-related complication (mean BMI 37.838.4 kg/m 2 ) and aimed to demonstrate the superiority of semaglutide 2.4 mg over placebo in BW lowering at 68 or 104 24 weeks as an adjunct to diet and physical activity 23

While this difference was not enough to meet the superiority bar, it did establish the non-inferiority of Fasenra

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Eat B12-rich or fortified foods if diet is part of the issue (animal foods, or fortified foods/supplements if plant-based)

they alter your biochemistry while active in your system