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Late-stage lead diversification coupled with quantitative nuclear magnetic resonance spectroscopy to identify new structure-activity relationship vectors at nanomole scale synthesis: application to loratidine, a human histamine H1 receptor inverse agonist

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To investigate whether the ROS is generated by the host or the pathogen, we inhibited Bd growth by increasing the temperature beyond the thermal optimum of Bd , and/or supplemented the cells with cysteine (a glutathione precursor) with the hypothesis that if ROS was pathogen generated it should decrease under these conditions