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Annu Rev Pharmacol Toxicol 41:237260 Coyle JT, Tsai G, Goff D (2003) Converging evidence of NMDA receptor hypofunction in the pathophysiology of schizophrenia

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N,Nbis-(2-mercaptoethyl) isophthalamide (NBMI), a lipophilic thiol-based chelator with selective affinity for ferrous iron, has demonstrated superior brain chelation efficacy in a mouse model of brain iron overload, making it a promising candidate for IN formulations if its solubility limitations can be addressed (Cheng et al., 2022)

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It is necessary to optimize the formula (such as adding antioxidants) or packaging materials (such as oxygen barrier bottles) to improve stability

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Second, glutamate-induced few changes in gene expression, implicating a direct effect on OL processes

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These pathways do not operate in isolation

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Lactic acid-producing bacteria may contribute to the development of gastric cancer by regulating the levels of lactic acid and lactylation modification 83

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