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Cu 2+ induces a conformational change into a more compact structure containing -helices that resists HDX and is protected from enzymatic hydrolysis by insulin degrading enzyme (IDE)

In addition, the intestinal biological barrier is also affected by liver disease

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This pathway can control the expression of PEBP1, ERK1/2, GPX4, FTH1, ACSL4, and COX2, thereby enhancing the function of hippocampal astrocytes and microglial cells in CUMS model mice (Yang et al., 2023) (Table 1)

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