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Trends Microbiol 16(7):309317 Ghuysen JM et al (1984) Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics

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From a market perspective, the demand for antifungal drugs continues to rise: The market is expected to expand at a compound annual growth rate (CAGR) of 2.81% from 2020 to 2033, with a size of 14.09 billion US dollars in 2024, expected to rise to 14.48 billion US dollars in 2025, and reach 18.08 billion US dollars by 2033 ( Figure 1 ) (Insights, 2025).However, the development and application of antifungal drugs face numerous challenges (Fisher et al., 2018