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We suggest that this discrepancy may result from limited sampling in Western blot analyses, given the established role of phosphorylated ERK phosphorylation in mediating microglial proliferation and morphological remodeling

Currently, different groups are developing methods to overcome these issues based on the incorporation of vascular endothelial growth factor (VEGF) and WNT7b or co-culture methods with mesodermal progenitors generating a vascular networks (Shi et al., 2020

More specifically, melatonin blocks ROS/RNS pathways, thus mitigating oxidative stress and damage to the cells, preventing mitochondrial fission and encouraging mitochondrial fusion, blocking the release of mitochondrial DNA, and preventing mitophagy, which is the phagocytosis of mitochondria

As a result, menopausal syndrome has a profound effect on womens quality of life (Sultana et al., 2023)

Journal of Infection and Public Health

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