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The etiology of HD is primarily attributed to the huntingtin protein (HTT) gene contains an abnormal number of CAG repeats, leading to the amplification of trinucleotide repeat sequences (TNR), specifically the CAG codon, resulting in the synthesis of an abnormal protein with an expanded polyglutamine (polyQ) tract (210, 211)

Glutathione A powerful antioxidant peptide that plays a critical role in detoxifying the body, reducing oxidative stress, and supporting immune function

This study uncovers E-cadherin as the epithelial host receptor of the major virulence factor InlA

GHK-Cu upregulates the expression of superoxide dismutase (SOD) and other endogenous antioxidant enzymes, helping skin combat the free radical damage that accelerates aging

Similarly, ICV pretreatment or peripheral post-treatment with the DEETGE-Cal-Tat peptide was also able to decrease Keap1-Nrf2 interaction in the rat hippocampal CA1 region after global cerebral ischemia (GCI) and, as a consequence, to induce Nrf2 target genes and a powerful neuroprotection of hippocampal-dependent cognitive function after GCI [302]

[DOI] [PubMed] [Google Scholar] 166.Akkaya S., Ulusoy D.M