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PMID: 10501046

Ferroptosis pathways and therapeutic targets in spinal cord injury Targeting ACSL4/LPCAT3/15-LOX Proanthocyanidin significantly reduced ACSL4 and ALOX15 levels and increased GSH, GPX4, Nrf2, and HO-1 expression to inhibit ferroptosis and promote functional recovery from SCI (Zhou et al., 2020b)

doi: 10.1007/s12551-020-00726-0 89 WangQMaLAnCWiseSGBaoS

1 10 4 cells were plated in 24-well plate and treated with TMZ and ferroptosis modulators for 72 or 120 h

Emerging evidence further expands this mechanistic landscape

Additionally, the area under the curve (AUC) for CU in rats was found to be 3.6 0.6 min/g/mL following oral administration of 500 mg/kg, and only 7.2 1.2 min/g/mL after intravenous administration of 10 mg/kg, further indicating poor absorption characteristics (Yang et al., 2007)