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Proc Natl Acad Sci USA 100 , 1298994, doi:10.1073/pnas.2134250100 (2003)

Dysregulation leads to oxidative stress, promoting inflammation and neurodegeneration

The observed association between the decreased GABA/Glx ratio in the IC and improvement in CARS score after bumetanide treatment provides evidence for the involvement of this cortex in ASD