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This functional interconnectivity endows the RCD system with high plasticity and signal redundancy, thereby explaining why monotherapeutic blockade of a single pathway often fails to rescue cells under pathological conditions [7]

Herein, the system Xc /GSH/GPX4 axis in the cytosol can be regarded as a potent regulator in lipid peroxidation, and the inhibition of this axis putatively accelerates the pathological process of ferroptosis (86)

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