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386,387 The increased chemokine levels are possibly caused by LPS stimulation in T2DM patients, which can predict hepatic steatosis

Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN (Negi et al., 2011a)