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These findings support a role for OLGs in pushing towards increased epigenetic/biological age, suggesting that this cell lineage ages faster than other brain cell types

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As outlined above, studies on non-glutathione disulfide substrates unfortunately regularly lack more detailed kinetic analyses, first, to confirm the efficient turnover of the substrate candidates and, second, to validate the dithiol mechanism

Both failures to achieve clinical translation could be associated with delivery-related issues, and some authors are working on including cilengitide in nanocarriers to overcome those issues [164]

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A total of 250 ng of target DNA was used per reaction