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Ethics declarations Conflict of interest The authors state they have no conflict of interest

NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key roles in pathways that modify aging

Data on inverse studies in advanced CKD and dialysis patients were reported, which led to the discovery of a potential phenomenon known as reverse epidemiology. Additional CVD risk factors associated with this phenomenon include blood pressure, plasma cholesterol levels, and body mass index [82]