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While the reaction of the therapeutic antibody seems relatively straightforward on the myeloma side (as MM cells are FcR-negative), more complex interactions occur with effector cells (FcR + ), where the antibody can engage both the Fab-binding site and one of the FcRs on the same cell ( Figure 3 ) (110)

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Comparison: Short-Term vs

This promoter is active in neural crest cells, and driving MYCN overexpression in these progenitor cells of NB causes the animals (Th- MYCN ) to develop tumors that closely resemble human NB (43)

The researchers also found that treated mice showed improved muscle recovery, requiring less time to return to baseline performance after intense exercise